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目的观察低频脉冲磁场(PEMF)对绝经后骨质疏松症(PMO)患者骨代谢标志物水平的影响及临床疼痛缓解效果。方法选取2014年1月至2015年6月初诊为PMO患者68例(含4例脱落病例),采用随机数字表法将患者分为观察组和对照组,各34例,观察组脱落1例,最终纳入33例;对照组脱落3例,最终纳入31例。对照组给予常规治疗,观察组在对照组基础上给予PEMF治疗,1个月为1个疗程,共3个疗程。检测血清Ⅰ型前胶原氨基端肽(PINP)、β胶原特殊序列(β-Cross laps)、钙(Ca)、磷(P)、碱性磷酸酶(ALP)值,发放视觉模拟评分(VAS)问卷评估疼痛程度。结果两组治疗后Ca、P、ALP对比差异无统计学意义(P均>0.05);观察组治疗后PINP显著降低且明显低于对照组[(45.26±10.17)ng/ml vs(56.41±10.89)ng/ml,P<0.05],β-Cross laps显著降低但与对照组对比无统计学差异[(487.2±110.7)pg/ml vs(539.6±128.4)pg/ml,P>0.05],观察组治疗后VAS评分显著低于对照组[(1.35±0.86)分vs(2.41±0.91)分,P<0.05]。结论 PEMF能改善PMO患者骨代谢异常,缓解疼痛症状。
Objective To observe the influence of low frequency pulsed magnetic field (PEMF) on the level of bone metabolism markers in postmenopausal osteoporosis (PMO) patients and the clinical pain relief. Methods A total of 68 PMO patients (including 4 exfoliated cases) with PMO newly diagnosed from January 2014 to June 2015 were selected. The patients were divided into observation group and control group by random number table method, 34 cases in each group, 1 case in observation group, The final inclusion of 33 cases; control group shedding in 3 cases, the final inclusion of 31 cases. The control group was given routine treatment. The observation group was treated with PEMF on the basis of the control group. One month was a course of treatment, a total of 3 courses. Serum type Ⅰ procollagen peptide (PINP), β-Cross laps, Ca, P, ALP and visual analogue scale (VAS) Questionnaire to assess the degree of pain. Results There was no significant difference in Ca, P and ALP between the two groups after treatment (P> 0.05). PINP in the observation group was significantly lower than that in the control group [(45.26 ± 10.17) ng / ml vs (56.41 ± 10.89 ) (P <0.05)], β-Cross laps was significantly lower than that of the control group (487.2 ± 110.7 pg / ml vs 539.6 ± 128.4 pg / ml, P> 0.05) The VAS score of the group after treatment was significantly lower than that of the control group [(1.35 ± 0.86) vs (2.41 ± 0.91) points, P <0.05]. Conclusion PEMF can improve abnormal bone metabolism in patients with PMO and relieve pain symptoms.