论文部分内容阅读
目的观察确诊的多肌炎和皮肌炎（ＰＭ／ＤＭ）患者皮肤、肌肉病理切片中浸润淋巴细胞的分型情况，研究分型与 ＰＭ／ＤＭ 临床表现的关系。方法采用免疫组化法测定 ４０例确诊的ＰＭ／ＤＭ患者皮肤、肌肉病理切片中淋巴细胞的具体百分比。结果ＤＭ患者皮下及肌膜间浸润淋巴细胞以Ｔ细胞为主，血管周围以Ｂ细胞多见。ＰＭ患者浸润淋巴细胞在皮肤、肌膜间及血管周围均以Ｔ细胞为主。结论细胞免疫反应参与ＰＭ发病，而在ＤＭ，细胞免疫及体液免疫反应均参与发病。
Objective To observe the classification of infiltrating lymphocytes in skin and muscle pathology of patients with confirmed polymyositis and dermatomyositis (PM / DM) and to study the relationship between classification and clinical manifestations of PM / DM. Methods Immunohistochemical method was used to determine the specific percentage of lymphocytes in skin and muscle pathology of 40 patients with PM / DM diagnosed. Results The infiltrating T lymphocytes in subcutaneous and interstitial infiltrating lymphocytes in TDM patients were predominant in DM patients, while the B cells were more common in peripheral blood vessels. Infiltrating lymphocytes in patients with PM are mainly T cells in the skin, periarterium and perivascular area. Conclusions Cellular immune response is involved in the pathogenesis of PM, while in DM, both cellular and humoral immune responses are involved in the pathogenesis.