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目的：观察补肾祛痰活血方对自然衰老和Ｄ－半乳糖（Ｄ－ｇａ１）所致衰老模型小鼠的学习记忆功能的影响。方法：采用避暗法和Ｍｏｒｉｓ水迷官法，研究补肾祛痰活血方对自然衰老和Ｄ－ｇａｌ衰老模型小鼠被动回避反射和空间分辨学习记忆能力的影响。结果：补肾祛痰活血方能增加Ｄ－ｇａ１衰老模型小鼠避暗实验潜伏期（Ｐ＜０．０５），减少其错误次数（Ｐ＜０．０５），并缩短其Ｍｏｒｉｓ迷官四个检测组合的潜伏期，还可明显增加自然衰老小鼠Ｍｏｒｉｓ迷官的Ｐ象限时间、穿环次数和游泳时间比（Ｐ＜０．０５），并缩短其潜伏期。结论：补肾祛痰活血方不但可改善衰老模型小鼠学习记忆能力而且可以减缓自然衰老小鼠学习记忆能力的减退，是一个较好的益智抗衰药物。
Objective: To observe the effect of Bushen Qutan Huoxue Recipe on the learning and memory function of natural aging and aging model mice induced by D-ga1. Methods: The effects of Bushen Qutan Huoxue Recipe on passive avoidance reflex and spatial resolution of learning and memory in mice model of natural aging and D-gal senescence were studied by the method of avoiding darkness and Moris water-maze method. Results: Bushen Qutan Huoxue can increase the latency of experiment (P <0.05), reduce the number of mistakes (P <0.05) and shorten the test of Moris fanatus in D-ga1 aging model mice (P <0.05), and shorten the incubation period of Morisoids in natural aging mice. Conclusion: Bushen Qutan Huoxue Recipe can not only improve the ability of learning and memory of aging mice, but also reduce the learning and memory abilities of mice of natural aging. It is a good anti-inflammatory medicine.