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反义核酸技术是利用碱基互补配对原则选择性抑制特定基因的复制、转录或翻译的一种基因治疗新方法。 1978年Stephenson和Zamenick首次提出了反义寡聚脱氧核糖核苷酸 (ASODN)抑制基因表达的概念[1 ] 。 1998年 ,第 1个治疗艾滋病患者巨细胞病毒 (CMV)感染的反义药物福米韦生(for
Antisense nucleic acid technology is a new method of gene therapy that selectively inhibits the replication, transcription or translation of a specific gene by using the principle of complementary base pairing. In 1978, Stephenson and Zamenick first proposed the concept of antisense oligodeoxyribonucleotide (ASODN) inhibition of gene expression [1]. In 1998, the first antitumor drug for treating cytomegalovirus (CMV) infection in HIV-infected patients