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早产是影响新生儿发病率和死亡率的主要原因。在我国,早产的发生率约为5%-15%,占新生儿死亡率的15%[1],早产儿死亡的主要原因为新生儿呼吸窘迫综合征(neonatal idiopathic repiratory distress syndrome,NRDS),而NRDS主要是由肺透明膜病变引起,故医学界又将NRDS称为新生儿肺透明膜病(hyaline membrane disease of newborn,HMD)。1972年,Graham Liggins[2]第一次报告产前使用糖皮质激素可以将HMD的风险从25.8%降至9%,1994年美国国立卫生研究所正式发表公
Preterm birth is the main reason that affects neonatal morbidity and mortality. In China, the prevalence of preterm birth is about 5% -15%, accounting for 15% of neonatal mortality [1]. The main cause of death in preterm infants is neonatal idiopathic repiratory distress syndrome (NRDS), neonatal respiratory distress syndrome The NRDS is mainly caused by hyaline membrane disease, so the medical community in turn NRDS called neonatal hyaline membrane disease (hyaline membrane disease of newborn, HMD). In 1972, Graham Liggins [2] first reported that prenatal use of glucocorticoids reduced the risk of HMD from 25.8% to 9% in prenatal delivery. In 1994, the National Institutes of Health officially published