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动脉粥样硬化的本质是血管壁的慢性炎症。长期的慢性微炎症状态可以加速血管的动脉粥样硬化过程。肾小球硬化与动脉粥样硬化在病理改变和病理生理机制上很相似,因此过去的许多临床和动物实验的研究已经证明,脂质失调是导致肾病进展和肾小球硬化的重要因素。而近年来国内外的最新研究更进一步证实炎症影响细胞水平的胆固醇稳态是加速脂质介导的动脉粥样硬化和肾脏损害的关键。
The nature of atherosclerosis is chronic inflammation of the blood vessel wall. Long-term chronic micro-inflammatory conditions can accelerate the atherosclerotic process of blood vessels. Glomerulosclerosis and atherosclerosis are pathological and pathophysiological mechanisms very similar, so many past clinical and animal studies have shown that lipid disorders is an important factor in the progression of nephropathy and glomerulosclerosis. In recent years, the latest research at home and abroad further confirmed that inflammation affects the cellular level of cholesterol homeostasis is the key to accelerate lipid-mediated atherosclerosis and kidney damage.