本文对大剂量静脉注射免疫球蛋白（ＩＶＩＧ）治疗新生儿ＡＢＯ溶血病（ＡＢＯＨＤＮ）进行了观察。治疗组２１例在光疗、白蛋白治疗的基础上，给予ＩＶＩＧ治疗，首次１ｇ／ｋｇ，以后每次４００ｍｇ／ｋｇ，每日１次，共用２～４次。结果治疗组无１例换血，全部治愈，而对照组２例发生核黄疸，其中１例死亡，在黄疸消失时间及住院天数方面，两组有显著性差异（Ｐ＜００１）。提示ＩＶＩＧ可明显减少溶血，降低胆红素浓度，减少核黄疸的发生，对重症病例可起到替代换血的作用 In this paper, high-dose intravenous immunoglobulin (IVIG) treatment of neonatal ABO hemolytic disease (ABOHDN) were observed. In the treatment group, 21 cases were given IVIG treatment on the basis of phototherapy and albumin treatment, the first 1g / kg, each 400mg / kg, once daily, for 2 to 4 times. Results There was no blood transfusion in the treatment group, and all of them were cured. In the control group, 2 cases had kernicterus jaundice. One case died of jaundice and the number of hospitalization days was significantly different (P <001). Tip IVIG can significantly reduce hemolysis, reduce the concentration of bilirubin, reduce the incidence of nuclear jaundice, for severe cases can play an alternative exchange transfusion