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探索了手性苯并噁嗪-2-酮二酚衍生物的高效合成,以甲氧基取代的2-羟基苯甲醛衍生物和手性环己二胺为起始原料合成手性双亚胺,后经低价钛促进下还原、偶联与固体光气作用,构建了含有甲氧基的手性苯并噁嗪-2-酮衍生物,通过官能团转化,利用三溴化硼还原得到相应的手性苯并噁嗪-2-酮二酚衍生物.在此基础上,考察了手性苯并噁嗪-2-酮二酚催化剂在醛与二乙基锌不对称加成中的应用.此方法为合成手性苯并噁嗪-2-酮二酚衍生物提供了一条有效途径.
The efficient synthesis of chiral benzoxazin-2-one-diphenol derivatives was explored. Chiral bis-imines were synthesized from methoxy-substituted 2-hydroxybenzaldehyde derivatives and chiral cyclohexanediamine , Followed by the promotion of low-cost titanium under the reduction, coupling and solid phosgene role in the construction of a methoxy-containing chiral benzoxazin-2-one derivatives, through the functional group conversion, the use of boron tribromide obtained corresponding Of chiral benzoxazin-2-one diphenol derivatives.On this basis, the application of chiral benzoxazin-2-one diphenol catalyst in the asymmetric addition of aldehyde and diethylzinc This method provides an effective route for the synthesis of chiral benzoxazin-2-one derivatives.