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目的分析不同病变程度冠状动脉粥样硬化性心脏病(冠心病)患者血浆Chemerin水平的变化特点。方法随机选择经冠状动脉造影(CAG)确诊的冠心病患者166例作为冠心病组,根据CAG结果中显示的冠脉病变支数又将冠心病组分为单支病变亚组55例,双支病变亚组70例,多支病变亚组41例。另选择CAG未见冠脉狭窄的患者30例作为非冠心病组。监测各组患者血浆Chemerin水平,比较冠心病患者与非冠心病患者以及冠脉病变程度不同亚组患者血浆Chemerin水平差异。结果冠心病各亚组血浆Chemerin水平均高于非冠心病组,差异均有统计学意义(P<0.05)。冠脉不同病变程度亚组间,随着冠脉病变支数的增加,血浆Chemerin水平逐渐增高,差异均有统计学意义(P<0.05)。结论血浆Chemerin水平在一定程度上可以预测冠心病以及冠脉病变程度。
Objective To analyze the changes of plasma Chemerin level in patients with coronary atherosclerotic heart disease (CHD) with different degree of lesion. Methods A total of 166 coronary artery disease patients diagnosed by Coronary Artery Angiography (CAG) were randomly selected as coronary heart disease group. According to the coronary lesion count shown by CAG results, 55 patients with coronary artery disease were divided into two groups: 70 cases of subgroup of lesions, 41 cases of multi-vessel disease subgroups. In addition, 30 patients with no coronary stenosis were selected as non-coronary heart disease group. The levels of plasma Chemerin in each group were monitored to compare the plasma levels of Chemerin in patients with coronary heart disease and non-coronary patients and in different subgroups of coronary artery disease. Results The levels of plasma Chemerin in all subgroups of CHD were significantly higher than those in non-CHD group (P <0.05). The plasma levels of Chemerin gradually increased with the number of coronary lesions increased in subgroups with different severity of coronary artery disease (P <0.05). Conclusion The level of Chemerin in plasma can predict the degree of coronary heart disease and coronary artery disease to a certain extent.