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全身型幼年特发性关节炎的主要特征是发热、关节炎、与热同行的皮疹、多浆膜炎、肝和(或)脾大同时伴有白细胞和血小板明显增高,ESR增快和贫血。其起病特点多急骤,多伴有明显的全身症状和关节局部炎症表现。由于病因不明,发病机制复杂,尽管在长期的治疗中不断更改治疗方案,但病情仍凶险,且反复,并难以控制,预后较差,需及时明确诊断;同时需对疾病的活动状态、病程和病情加以综合评估,及时发现预后不良的早期指标,及时调整以糖皮质激素联用非生物改变病情药物(DMARDs)和生物DMARDs为主的治疗方案,从而改善预后。
The main features of systemic juvenile idiopathic arthritis are fever, arthritis, rash with heat, polyserositis, marked increases in white blood cells and platelets accompanied by rapid increases in ESR and anemia in the liver and / or splenomegaly. Its onset more rapid features, and more accompanied by obvious systemic symptoms and local joint inflammation performance. Due to unknown etiology and complicated pathogenesis, the disease is still dangerous and repetitive and difficult to control despite the continual change of treatment regimens in long-term treatment. The prognosis is poor and timely diagnosis is needed. At the same time, the disease status, course of disease and Comprehensive evaluation of the disease, timely detection of poor prognosis of the early indicators, timely adjustment of glucocorticoid combined with non-biological change of the disease drugs (DMARDs) and biological DMARDs-based treatment programs to improve the prognosis.