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休克为一复杂的病理生理过程,其发病机制尚有许多争论。传统学说认为“交感神经活动亢进是休克的始动环节,并贯穿于休克的始终。”而我国临床使用莨菪类药治疗休克获得成功,推测迷走神经活动亢进在休克中亦占有重要地位。目前,国外正进行钙通道阻滞剂治疗休克的研究,而钙不仅具有心血管效应,还决定神经递质的发放。为了阐明迷走神经活动在休克发病中的作用,我们使用东莨菪碱(Scopolamine)和钙通道阻滞剂—异搏停(Verapamil)治疗休克家兔,以进一步探讨休克的发病机制。
Shock is a complex pathophysiological process, the pathogenesis there are many controversies. The traditional doctrine that “sympathetic activity hyperkinesia is the first step in shock, and runs through the shock of the end.” And clinical use of Chinese medicine treatment of scopolamine success, it is speculated that vagus nerve activity in shock also plays an important role. Currently, foreign countries are conducting calcium channel blockers in the study of shock, and calcium not only has a cardiovascular effect, but also determines the release of neurotransmitters. To elucidate the role of vagal activity in the pathogenesis of shock, we used scopolamine and calcium channel blocker verapamil to treat shocked rabbits to further investigate the pathogenesis of shock.