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目的:探索成年女性复发性口腔溃疡患者的维生素B12、叶酸水平,并分析维生素B12、叶酸缺乏与口腔黏膜异常程度的相关性。方法:对比70例复发性口腔溃疡成年女性患者(ROU组)和70例成年女性口腔黏膜正常组(非ROU组)维生素B12、叶酸水平的差异,另外将ROU组按照轻中重程度分为三组,分别为轻型口腔溃疡组(A组)、中型口腔溃疡组(B组)和重型口腔溃疡组(C组),比较这三组中维生素B12、叶酸水平的差异,分析维生素B12、叶酸缺乏与口腔黏膜异常的相关性。结果:ROU组患者维生素B12、叶酸水平明显低于非ROU组,A组患者维生素B12、叶酸水平低于B组,B组患者维生素B12、叶酸水平低于C组,A组与C组相比差异有统计学意义,且维生素B12、叶酸缺乏与口腔黏膜异常呈正相关。结论:成年女性复发性口腔溃疡患者维生素B12、叶酸水平缺乏,且维生素B12、叶酸缺乏与口腔黏膜异常程度呈正相关,是复发性口腔溃疡发作的重要因素。
Objective: To explore the vitamin B12 and folic acid levels in adult female patients with recurrent oral ulcer and analyze the correlation between vitamin B12, folic acid deficiency and oral mucosal abnormalities. Methods: The differences of folic acid levels between vitamin B12 and 70 normal adult female patients (ROU group) and 70 adult female oral mucosa normal subjects (non-ROU group) were compared in 70 patients with recurrent oral ulcer. In addition, the ROU group was divided into three groups (Group A), medium-sized oral ulcer (group B) and severe oral ulcer (group C). The differences of vitamin B12 and folic acid levels among the three groups were compared. Vitamin B12, folic acid deficiency Correlation with oral mucosal abnormalities. Results: The levels of vitamin B12 and folic acid in ROU group were significantly lower than those in non-ROU group, the vitamin B12 in group A was lower than that in group B, the vitamin B12 in group B was lower than that in group C The difference was statistically significant, and vitamin B12, folic acid deficiency and oral mucosal abnormalities were positively correlated. CONCLUSION: Vitamin B12 and folate levels are deficient in patients with recurrent oral ulcer in adults. Vitamin B12 and folic acid deficiency are positively correlated with the degree of oral mucosal abnormalities and are important factors in the development of recurrent oral ulcer.