大肠癌是我国常见的恶性肿瘤之一,常用的手术、化疗、放疗等传统的治疗方式均未能使其疗效得到明显的提高。随着分子生物学及基因工程的发展,基因治疗已成为研究重点,其中自杀基因治疗是一种较为有效的具有临床应用潜力的治疗策略。它是把某些能将非毒性药物代谢成细胞毒性药物 Colorectal cancer is one of the most common malignant tumors in our country. The traditional methods such as surgery, chemotherapy and radiotherapy failed to improve the curative effect. With the development of molecular biology and genetic engineering, gene therapy has become a research focus, of which suicide gene therapy is a more effective treatment strategy with clinical potential. It is some of the non-toxic drugs can be metabolized into cytotoxic drugs