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目的探讨胸腔感染患者血清降钙素原(PCT)及C反应蛋白(CRP)的变化以及其与患者预后的关系。方法 138例胸腔感染患者,将其分为重度感染组和非重度感染组,并选择同期本院体检的50例健康受检者作为对照组,分析3组治疗前及治疗后第1、3、5天血清PCT和CRP变化。138例患者根据预后分为治愈组、好转组和加重/死亡组,分析治疗前PCT与CRP水平与患者预后关系。结果两组患者治疗前及治疗第1、3、5天PCT、CRP水平均显著高于对照组(P<0.05);且随感染时间延长,PCT和CRP水平逐渐升高,于治疗第3天到达最高水平后逐渐下降,治疗第5天时PCT和CRP水平显著低于第3天(P<0.05),与第1天比较差异无统计学意义(P>0.05),治愈组PCT和CRP水平显著低于好转组和加重/死亡组患者,差异有统计学意义(P<0.05);加重/死亡组患者PCT及CRP水平比好转组患者有显著上升(P<0.05)。结论血清PCT及CRP可以作为临床胸腔感染诊断和预后情况判断的辅助指标。
Objective To investigate the changes of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with pleural infection and their relationship with prognosis. Methods One hundred and thirteen patients with thoracic cavity infection were divided into severe infection group and non-severe infection group, and 50 healthy subjects in our hospital were selected as the control group. 5 days serum PCT and CRP changes. 138 patients were divided into cured group, remission group and aggravating / death group according to the prognosis. The relationship between the level of PCT and CRP before treatment and the prognosis of patients was analyzed. Results The levels of PCT and CRP in both groups before treatment and on the 1st, 3rd and 5th treatment were significantly higher than those in the control group (P <0.05). The levels of PCT and CRP increased gradually with the prolongation of infection time. On the third day After reaching the highest level, the levels of PCT and CRP gradually decreased. The levels of PCT and CRP on the 5th day of treatment were significantly lower than those on the 3rd day (P <0.05), and there was no significant difference between the 5th day and the 1st day (P> 0.05) (P <0.05). The PCT and CRP levels in patients with exacerbations / deaths were significantly higher than those in patients with exacerbations (P <0.05). Conclusions Serum PCT and CRP can be used as auxiliary indicators for diagnosis and prognosis of clinical chest infection.