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目的 :研究冬苓扶正液与氟尿嘧啶 (FU)配伍用对小鼠移植肿瘤S180、H2 2、Lewis的抑瘤作用及对FU所致小鼠免疫功能抑制的保护作用。方法 :按照抗癌药物筛选规程进行体内抑瘤实验 ;采用FU制备免疫功能低下模型 ,测定冬苓扶正液与FU配伍用对小鼠白细胞计数、免疫器官重量、腹腔巨噬细胞吞噬功能的影响。结果 :不同剂量的冬苓扶正液与FU配伍用均能明显提高FU对小鼠移植肿瘤S180、H2 2、Lewis的抑瘤率 ,其中高剂量组抑瘤效果最佳 ,配伍用且能明显拮抗FU所致白细胞下降、胸腺、脾脏萎缩及腹腔巨噬细胞功能降低等毒副作用。结论 :冬苓扶正液与FU配伍用具有明显提高FU抗肿瘤及降低其毒性作用。
OBJECTIVE: To study the antitumor effect of combination of Fuling and Fluorouracil (FU) on mouse tumor-bearing S180, H2 2 and Lewis and the protective effect on the immunosuppression induced by FU in mice. Methods: In vivo anti-tumor experiments were conducted according to the anti-cancer drug screening protocol. The model of immunocompromised mice was established by FU. The effects of combination of TEFL and FU on the white blood cell count, weight of immune organs and phagocytosis of peritoneal macrophages were determined. Results: Tung Ling Fuzheng decoction with different dosages can obviously increase the inhibitory rate of FU on S180, H2 2 and Lewis transplanted tumors in mice, of which the high dose group had the best antitumor effect, and could obviously antagonize with compatibility FU-induced leukopenia, thymus, spleen atrophy and reduced peritoneal macrophage function and other toxic side effects. Conclusion: The combination of Dongling Fuzheng and FU can obviously improve the anti-tumor effect and reduce the toxicity of FU.