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目的:对Notch1与Cyclin D1在不同组织类型乳腺导管疾病中的不同表达进行探索,研究乳腺导管碍于乳腺导管增生症的发生与彼此之间的关系。方法:选取我院于2014年6月至2015年6月收治的200例乳腺增生症和乳腺癌患者作为研究对象,其中正常乳腺导管组织、乳腺导管普通增生组织、乳腺导管不典型增生组织、乳腺导管原位癌组织、乳腺导管浸润性癌组织中Notch1受体蛋白与Cyclin D1蛋白表达各40例。结果:经统计发现,Notch1与Cyclin D1在正常乳腺导管组织、导管普通增生组织、导管原位癌以及导管浸润性癌之间的阳性表达率分别为56%、61%、57%和66%;26%、31%、34%、28%。Notch1与Cyclin D1在上述四种形态下的阳性表达率均不具有统计学意义(P>0.05),但在其他亚组之间的比较差异显著,具有统计学意义(P<0.05)。结论:乳腺增生症和乳腺癌的发生具有一定的相关性,其中乳腺导管癌的发生与Notch1表达的降低以及Cyclin D1表达的增高可能具有一定的联系性。
OBJECTIVE: To explore the different expression of Notch1 and Cyclin D1 in different types of breast ductal diseases, and to study the relationship between breast duct and breast ductal hyperplasia. Methods: 200 cases of breast hyperplasia and breast cancer admitted to our hospital from June 2014 to June 2015 were selected as the research object. Normal breast ductal tissue, common ductal hyperplasia tissue, atypical ductal hyperplasia, breast Ductal carcinoma in situ, breast ductal invasive carcinoma of Notch1 receptor protein and Cyclin D1 protein expression in 40 cases. Results: The positive rates of Notch1 and Cyclin D1 were 56%, 61%, 57% and 66% respectively in normal breast ductal tissue, ordinary ductal hyperplasia, ductal carcinoma in situ and ductal carcinoma. 26%, 31%, 34%, 28%. The positive expression rate of Notch1 and Cyclin D1 in the above four forms had no statistical significance (P> 0.05), but there was significant difference between the other subgroups (P <0.05). CONCLUSIONS: Hyperplasia of mammary glands and breast cancer are related to each other. The occurrence of breast ductal carcinomas may be related to the decrease of Notch1 expression and the increase of Cyclin D1 expression.