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应用ＣＤ４４ｖ６单克隆抗体对３０例口腔鳞状细胞癌进行了免疫组织化学研究。实验发现：ＣＤ４４ｖ６在正常口腔粘膜上皮中的基底细胞层及近基底１／３的上皮细胞膜上呈阳性表达，上皮表层细胞几乎呈阴性表达。在３０例鳞状细胞癌的免疫组织化学染色中大部分鳞状细胞癌的癌细胞染色阳性，但染色强度随肿瘤的分化程度不同而不同，分化高的癌巢上皮细胞膜染色均匀而浓重，分化差的癌巢上皮细胞膜染色弱而呈细线状，转移灶内癌巢上皮ＣＤ４４ｖ６染色较弱。实验表明：ＣＤ４４ｖ６的表达在判断癌的分化、浸润、转移中有重要意义
Immunohistochemistry was performed on 30 cases of oral squamous cell carcinoma using CD44v6 monoclonal antibody. It was found that CD44v6 was positive in the basal cell layer and nearly 1/3 of the epithelial cell membrane in normal oral mucosa epithelium, and the epithelial cells almost negatively expressed. In 30 cases of squamous cell carcinoma immunohistochemical staining most of squamous cell carcinoma of the cancer cells stained positive, but the staining intensity varies with the degree of differentiation of the tumor differentiated, high differentiated cancer nest epithelial cell membrane staining uniform, thick, differentiated Poor cancer nest epithelial cell membrane staining was weak and thin line shape, metastasis lesions nest epithelial CD44v6 staining weaker. Experiments show that: CD44v6 expression in the judgment of cancer differentiation, invasion, metastasis is of great significance