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Streptozotocin(SZN)是一种广谱抗菌素,能抑制大肠杆菌的 DNA 合成,可以影响细胞增殖周期的每一个阶段。对人类肿瘤的抑制,包括胰岛细胞瘤、恶性类癌、肺癌、口腔鳞状细胞癌、滑膜肉瘤及胆囊腺癌等。毒性作用在某些患者可出现骨髓抑制及肾中毒。本文报告用 SZN 治疗22例肿瘤患者,包括7例胰腺肿瘤(4例腺癌、2例胰岛细胞癌,1例未确定)6例直肠乙状结肠癌,3例恶性黑色素瘤,6
Streptozotocin (SZN) is a broad-spectrum antibiotic that inhibits DNA synthesis in E. coli and can affect every stage of the cell proliferation cycle. Inhibition of human tumors, including islet cell tumors, malignant carcinoid, lung cancer, oral squamous cell carcinoma, synovial sarcoma and gallbladder adenocarcinoma. Toxicity In some patients, myelosuppression and nephrotoxicity can occur. This article reports 22 cases of tumor patients treated with SZN, including 7 cases of pancreatic tumors (4 cases of adenocarcinoma, 2 cases of islet cell carcinoma, 1 case of undefined) 6 cases of rectal sigmoid colon cancer, 3 cases of malignant melanoma, 6