目的:探讨抗环瓜氨酸肽抗体(抗CCP抗体)与类风湿关节炎(RA)的临床表现的相关性。方法:收录139例RA患者的临床表现及X线分期。以酶联免疫吸附(ELISA)法测定其抗CCP抗体水平,抗类风湿因子(RF)采用乳胶凝集法测定,魏氏法测定血沉(ESR)。结果:抗CCP抗体阳性患者在血沉的分布(阴性vs阳性)、X线分期的分布(Ⅰ+Ⅱ期vsⅢ+Ⅳ期)、关节外表现的分布(<3个vs≥3个)、DAS 28评分的分布(>5.1分vs≤5.1分)方面与抗CCP抗体阴性患者比较,差异均有高度统计学意义(χ2=14.89、6.87、14.63、7.27,均P<0.01)。结论:抗CCP抗体与病情活动的指标(血沉、DAS 28评分)有关,与RA患者关节破坏程度(X线分期)和关节外表现有关。 Objective: To investigate the relationship between anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and clinical manifestations of rheumatoid arthritis (RA). Methods: The clinical manifestations and X-ray staging of 139 RA patients were included. The level of anti-CCP antibody was measured by enzyme-linked immunosorbent assay (ELISA). The anti-rheumatoid factor (RF) was determined by latex agglutination. The ESR was measured by Weiss method. Results: The distribution of anti-CCP antibody in ESR (negative vs positive), X-ray stage (Ⅰ + Ⅱ vs Ⅲ + Ⅳ), the distribution of extra-articular findings (<3 vs≥3), DAS 28 There was a statistically significant difference in the distribution of scores (> 5.1 points vs≤5.1 points) with anti-CCP antibody negative patients (χ2 = 14.89,6.87,14.63,7.27, all P <0.01). CONCLUSIONS: The anti-CCP antibody is associated with the index of disease activity (ESR, DAS 28 score) and the degree of joint destruction (X-ray staging) and extra-articular manifestations in patients with RA.