目的:观察桂附地黄丸对肾阳虚抑郁症大鼠行为学改变的影响。方法:大鼠按单纯随机抽样分为5组,空白组、阳性对照组、高剂量组、中剂量组、低剂量组。除空白组外均采用氢化可的松与慢性不可预知温和应激结合复制肾阳虚抑郁症大鼠模型后,阳性对照组给予盐酸氟西汀持续治疗14天;桂附地黄丸高、中、低剂量组按每天20.3g/kg、13.5g/kg、6.08g/kg,每次稀释为4mL,治疗30天。结果:造模21天后,各用药组与空白组比较,水平得分、垂直得分、清洁运动次数降低,中央格停时间延长、粪便粒数增多,糖水消耗、糖水偏爱减少、强迫游泳不动时间延长等方面均有差异(P<0.05,P<0.01);高剂量组在55天末时在水平得分、清洁运动次数与低剂量组比较均有差异(P<0.05),在糖水消耗、糖水偏爱方面与低剂量组均有差异(P<0.01)。结论:桂附地黄丸高、中剂量组、阳性对照组肾阳虚抑郁症大鼠行为均明显改善,且具有一定的量效关系。抑郁症的主要病机可能为肾阳虚。 Objective: To observe the effects of Gui Fu Di Huang Wan on behavioral changes in rats with deficiency of kidney yang. Methods: The rats were divided into 5 groups, blank group, positive control group, high dose group, middle dose group and low dose group according to simple random sampling. In addition to the blank group were used hydrocortisone and chronic unpredictable mild stress combined with replication of rat model of kidney yin deficiency, the positive control group was given fluoxetine hydrochloride for 14 days; Gui Fu Di Huang Wan high, Low-dose group according to daily 20.3g / kg, 13.5g / kg, 6.08g / kg, each diluted 4mL for 30 days. Results: After 21 days of modeling, compared with the blank group, the horizontal score, the vertical score, the number of cleansing motions, the prolonged central grid stop time, the number of excrement particles, the sugar consumption, the preference of syrup decreased, the forced swimming time was longer (P <0.05, P <0.01). There was a significant difference between the high-dose group at the 55th day and the low-dose group (P <0.05) There were differences between the two groups (P <0.01). Conclusion: The behavior of rats with kidney-yang deficiency and depression in Guifu Dihuang Pill group was significantly improved with high dose, middle dose and positive control group, and had some dose-effect relationship. The main pathogenesis of depression may be kidney yang.