围生期窒息所致脑缺氧缺血损伤是新生儿期危害最大的常见病,常造成新生儿的死亡或不同程度的致残。迄今为止,对脑缺氧缺血损伤的确切发病机制尚认识不足。目前,比较普遍易接受的学说有:能量衰竭学说,再灌注损伤和氧自由基损伤学说,钙超载学说,兴奋性氨基酸的毒性作用以及细胞因 Perinatal asphyxia due to hypoxic-ischemic brain damage is the most common neonatal harm, often resulting in neonatal death or varying degrees of disability. So far, the exact pathogenesis of hypoxic-ischemic brain damage is still not fully understood. At present, the more generally accepted doctrines are: energy failure theory, reperfusion injury and oxygen free radical damage theory, calcium overload theory, the toxic effects of excitatory amino acids and cytokines