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根据ＴＸＡ２／ＰＧＨ２ 受体拮抗剂的结构特征，设计合成了１６ 个２ ，２′二硫代双苯甲酸衍生物，部分目标化合物在体外对ＡＤＰ 诱导的兔血小板聚集均有不同程度的抑制作用，其中化合物（Ｉ３） 活性较强．
According to the structural characteristics of TXA2 / PGH2 receptor antagonist, 16 2, 2’-dithiobisbenzoic acid derivatives were designed and synthesized, and some of the target compounds inhibited ADP-induced rabbit platelet aggregation in vitro to varying degrees , Of which compound (I3) is more active.