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目的探讨降钙素原(PCT)在诊断早产儿医院内感染的临床价值。方法选取2014年1-10月在该院住院的早产儿(胎龄<37周)108例为研究对象,其中感染组早产儿58例,非感染组早产儿50例。住院后使用抗菌素前抽取静脉血检测PCT与超敏C反应蛋白(hs-CRP,)并对PCT与hs-CRP诊断早产儿医院内感染进行比较。结果医院内感染组PCT与hs-CRP的含量均明显增高,与非感染组比较,差异有统计学意义(P<0.01)。而医院内感染组早产儿PCT与hs-CRP两种方法阳性率比较,PCT(93.10%)优于hs-CRP(75.86%),差异有统计学意义(P<0.05)。PCT检测在早产儿医院内感染敏感性及准确性较高,同时可依据PCR升高水平及动态观察血中PCT的变化对医院内感染程度,疗效观察及预后判断具有一定的临床价值,有助于指导临床及时合理应用抗菌素。结论 PCT对早产儿医院内感染的早期诊断有重要价值,可作为早产儿医院内感染的早期快速检测指标,其敏感度、特异性优于hs-CRP。
Objective To investigate the clinical value of procalcitonin (PCT) in the diagnosis of nosocomial infection in premature infants. Methods A total of 108 preterm infants (gestational age <37 weeks) hospitalized in our hospital from January to October 2014 were selected as the study subjects. Among them, 58 were premature infants in infected group and 50 were premature infants in non-infected group. PCT and hs-CRP were detected in venous blood before inpatient use of antibiotics and PCT and hs-CRP were compared in the diagnosis of nosocomial infections in preterm infants. Results The contents of PCT and hs-CRP in the nosocomial infection group were significantly higher than those in the non-infected group, the difference was statistically significant (P <0.01). The positive rates of PCT and hs-CRP in preterm infants with infection in the hospital group were higher than those of hs-CRP (93.10%) in PCT (75.86%) (P <0.05). PCT detection in preterm children with high sensitivity and accuracy of hospital infection, at the same time based on the level of PCR and dynamically observe changes in PCT blood levels of hospital infection, efficacy and prognosis of prognosis has some clinical value, is helpful To guide the clinical timely and rational use of antibiotics. Conclusion PCT has important value in the early diagnosis of nosocomial infection in premature infants. It can be used as an early rapid detection index for nosocomial infection in premature infants. Its sensitivity and specificity are better than hs-CRP.