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目的:检测基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)在食管鳞状细胞癌组织中的表达情况,并探讨其与食管癌临床病理特征的关系。方法:采用免疫组织化学方法检测MMP-2蛋白在106例食管鳞癌和50例癌旁正常食管上皮组织中的表达情况。结果:MMP-2蛋白在食管鳞癌组织中的阳性表达率为80.2%,与正常食管上皮组织相比,差异有统计学意义(P<0.05);MMP-2蛋白表达阳性率在食管鳞癌不同分化程度、浸润深度、淋巴结有无转移和不同临床分期中的差异具有统计学意义(P<0.05)。结论:MMP-2蛋白在食管磷癌组织中呈高表达,对其检测在食管鳞癌浸润、转移的预后判断上有重要临床意义。
OBJECTIVE: To detect the expression of matrix metalloproteinase-2 (MMP-2) in esophageal squamous cell carcinoma and to investigate its relationship with the clinicopathological features of esophageal carcinoma. Methods: The expressions of MMP-2 protein in 106 esophageal squamous cell carcinomas and 50 normal esophageal squamous cell carcinomas were detected by immunohistochemistry. Results: The positive rate of MMP-2 protein in esophageal squamous cell carcinoma was 80.2%, which was significantly different from that in normal esophageal epithelium (P <0.05). The positive rate of MMP-2 protein in esophageal squamous cell carcinoma There were significant differences in different degrees of differentiation, depth of invasion, lymph node metastasis and clinical stage (P <0.05). Conclusion: MMP-2 protein is overexpressed in esophageal carcinoma, which has important clinical significance in predicting the prognosis of esophageal squamous cell carcinoma.