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目的：了解运动神经元病（ＭＮＤ）患者认知障碍的特点。方法：采用韦氏成人智力量表、临床记忆量表和体感刺激诱发的事件相关脑诱发电位，对１８例ＭＮＤ患者和２４例健康人进行了测验比较。结果：ＭＮＤ患者可出现不同程度的智能、记忆障碍。其中语言智商（３３．３％）、操作智商（３８．９％）、全量表智商（２７．８％）和记忆商（３８．９％）在边界以下。本组患者表现为皮质兼皮质下智能障碍的特征。其认知电位Ｐ３００的潜伏期与对照组相比明显延长（ｐ＜０．００１），波幅明显降低（ｐ＜０．００１）。
Objective: To understand the characteristics of cognitive impairment in patients with motor neuron disease (MND). Methods: Eighteen patients with MND and 24 healthy subjects were tested by Wechsler Adult Intelligence Scale, Clinical Memory Scale and somatosensory evoked potential brain evoked potentials. Results: MND patients may have some degree of intelligence and memory impairment. Language IQ (33.3%), IQ (38.9%), full scale IQ (27.8%) and memory (38.9%) were below the border. This group of patients showed the characteristics of cortical and subcortical intelligence disorders. The latency of cognitive potential P300 was significantly prolonged compared with the control group (p <0.001), and the amplitude was significantly decreased (p <0.001).