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骨形态发生蛋白(bone morphologenetic protein,BMP)是转化生长因子β超家族的成员,可诱导原始间质细胞向骨与软骨趋化、增殖、分化。正常的BMP含量是维持骨的结构和功能的重要条件之一,BMP在体内诱导成骨的作用,已被REN等[1]证实。骨形态发生蛋白-2(BMP-2)为BMP家族中的重要成员。本文通过检测股骨头坏死模型大鼠阶段性病症,观察BMP-2在骨形成、骨愈合及治疗骨缺损中的作用,为股骨头坏死的治疗提供了新思路。
Bone morphogenetic protein (BMP), a member of the transforming growth factor β superfamily, induces the primitive mesenchymal cells to chemoattract, proliferate and differentiate into bone and cartilage. Normal BMP content is to maintain the structure and function of bone one of the important conditions, BMP in vivo induced osteogenesis, has been REN et al [1] confirmed. Bone morphogenetic protein-2 (BMP-2) is an important member of the BMP family. This article examines the stage disorders of the rat model of osteonecrosis of the femoral head, observes the role of BMP-2 in bone formation, bone healing and treatment of bone defects, providing a new idea for the treatment of osteonecrosis of the femoral head.