1978年Lee等报道从疫区黑线姬鼠的肺组织中发现出血热抗原物质后,病毒分离相继获得成功。从而对本病的病原学、流行病学及临床学的研究是一个很大的推动。仅将近年来临床学的研究进展作一综述。关于发病机理及病理生理的研究概况1.病理改变:近年来通过半薄切片和电镜观察发现毛细血管及小血管的病变非常显著,可呈现节段性和不对称性的收缩或扩张,管腔 In 1978, Lee et al reported successful isolation of the virus from hemorrhagic fever antigens in lung tissues of Apodemus agrarius in the epidemic area. Thus the etiology, epidemiology and clinical studies of this disease is a big boost. Only in recent years clinical research advances are reviewed. About the pathogenesis and pathophysiology research overview 1. Pathological changes: In recent years through the semi-thin sections and electron microscopy showed capillary and small vessel lesions is very significant, showing segmental and asymmetric contraction or expansion, the lumen