目的 了解成纤维细胞在肾间质纤维化中的作用。方法 在原代和传代培养中,观察来自间质纤维化人肾的成纤维细胞生长及凋亡情况。结果 发现来自间质纤维化传脏的成纤维细胞分化异常,生长过度凋亡减少。结论 肾间质纤维化发病机理不仅与成纤维细胞过度生长有关,也可能与其凋亡减少有关。 Objective To investigate the role of fibroblasts in renal interstitial fibrosis. Methods In primary and subculture, the growth and apoptosis of fibroblasts from interstitial fibrosis human kidney were observed. As a result, fibroblasts derived from interstitial fibrosis were found to be abnormally differentiated, and overexpression of apoptosis was reduced. Conclusions The pathogenesis of renal interstitial fibrosis is not only related to the overgrowth of fibroblasts, but also to the decrease of apoptosis.