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在豚鼠实验性冠状动脉痉挛动物模型上,用浮置微电极技术,观察心肌细胞AP的改变以及亚硒酸钠对此改变的影响。静脉注射垂体后叶素(0.3 U/kg)后,APH降低28%,APD_(50)与APD_(50)分别缩短17%与15%。静注亚硒酸钠,AP未见明显变化。但在亚硒酸钠注射的基础上再给予同剂量的垂体后叶素,则上述各项指标减少程度均较单独注射垂体后叶素为轻。结果提示亚硒酸钠对实验性冠脉痉挛所诱发的AP改变有一定对抗作用。
In guinea pig experimental coronary artery spasm animal model, floating microelectrode technique was used to observe changes of cardiomyocytes AP and the effect of sodium selenite on this change. After intravenous injection of pituitrin (0.3 U / kg), APH decreased by 28% and APD_ (50) and APD_ (50) decreased by 17% and 15%, respectively. Intravenous sodium selenite, AP no significant change. However, sodium selenite injection on the basis of the same dose of pituitrin, then the above indicators were reduced compared with pituitrin injection alone was light. The results suggest that sodium selenite has some antagonistic effect on the AP changes induced by experimental coronary spasm.