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本文报告了临床已确诊为多发性硬化(MS)的41例患者的磁共振成像(MRI)和脑脊液(CSF)检查,以评定上述两项检查的临床意义.所有病例均符合Schumacher临床诊断标准,年龄22～62岁(平均年龄39.4±10岁),病程1～24年(平均7.4±6.5年),结果:76%(31/41)患者MRI可见脑室周围及白质病变,病程少于3年的患者中45%(5/11)MRI异常,病程长于3年的患者中87%(26/30)MRI异常.二者统计学上有显著差异(F〔1.39〕=5.6; P<0.02),但在年龄、性别、发病年龄方面无显著差异.CSF检查发现76%(31/41)患者CSF中IgG、MBP和/或单克隆带增加.其中CSF异常与患者年龄、性别、发病年龄、MRI分级及病程无
In this paper, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination of 41 patients with clinically diagnosed multiple sclerosis (MS) were reported to assess the clinical significance of these two tests.All the cases met the Schumacher clinical diagnostic criteria, The patients were 22 to 62 years old (mean age 39.4 ± 10 years) and 1 to 24 years (mean 7.4 ± 6.5 years). Results: 76% (31/41) of patients had MRI findings of periventricular and white matter lesions with less than 3 years Of patients had abnormalities of MRI in 45% (5/11) of the patients and 87% (26/30) of MRI abnormalities in patients longer than 3 years.The statistical difference was statistically significant (F [1.39] = 5.6; P <0.02) , But there were no significant differences in age, sex and age of onset.CSF examination revealed an increase of IgG, MBP and / or monoclonal bands in CSF of 76% (31/41) patients, with abnormalities of CSF associated with age, gender, age of onset, MRI classification and course of disease without