论文部分内容阅读
目的 :探讨健脾温中方对脾胃虚寒型肠易激综合征 (IBS)的作用机制。方法 :将 5 0只 Wistar大鼠 (180±2 0 ) g,随机分为 5组 :正常组、模型组、中药大剂量组、中药小剂量组、得舒特组。分别给予健脾温中方 ,得舒特 ,0 .9% Na Cl溶液灌胃。观察体重、稀便级、碳末推进率、血浆和组织中的生长抑素 (SS)、血管活性肠肽 (VIP)的含量变化。结果 :健脾温中方明显改善脾胃虚寒型 IBS的大鼠症状体征 ,且成一定的量效关系 ,降低 SS、VIP的含量。结论 :健脾温中方可通过调整紊乱的胃肠激素分泌、释放来达到治疗目的。
Objective : To explore the mechanism of Jianpi Wenzhong recipe on irritable bowel syndrome (IBS). METHODS: A total of 50 Wistar rats (180±20) g were randomly divided into 5 groups: normal group, model group, high-dose Chinese medicine group, small-dose Chinese medicine group, and Deshuet group. Given Spleen Wenzhong Fang, respectively, Shute, 0.9% NaCl solution gavage. Changes in body weight, stool level, carbon propulsion rate, levels of somatostatin (SS), and vasoactive intestinal peptide (VIP) in plasma and tissues were observed. Results : Jianpi Wenzhong significantly improved the symptoms and signs of spleen-stomach-deficiency-type IBS in rats, and became a certain dose-effect relationship, and reduced the content of SS and VIP. Conclusion : Jianpi Wenzhong can achieve therapeutic goals by adjusting the secretion and release of disordered gastrointestinal hormones.