Recently, cellulose nanofibril (CNF) has emerged as a promising, sustainable reinforcement with outstanding potential in material science. Owing to the properties of CNF, it has been explored in food, cosmetic, and pharmaceutical applications, as well as in industrial applications such as paints, drill muds, packaging, and papermaking. The application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of cellulose. Numerous studies and patents have reported on the manufacturing, properties, and applications of nanocellulose. This present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking.