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作者研究了以片剂或悬剂的方式给予口服负荷剂量卡马西平的药动学和副作用。 对住在一所医院癫痫病房接受作为出院带药(卡马西平)的一些病人于空腹时随机分别给予8mg·kg~(-1)负荷剂量口服。在试验前和接受负荷剂量后12h抽取血液标本。主观和客观地评估副作用。采用高效液相层析法测定血清总的与游离卡马西平浓度以及卡马西平-10,11-环氧化物(CBZE)浓度。
The authors investigated the pharmacokinetics and side effects of oral loading of carbamazepine in the form of tablets or suspensions. Some patients admitted to a hospital epilepsy ward as discharged medication (carbamazepine) were randomly assigned to receive a loading dose of 8 mg · kg -1 at fasting time. Blood samples were taken 12 h before and after the loading dose. Subjective and objective assessment of side effects. Serum total and free carbamazepine concentrations and carbamazepine-10,11-epoxide (CBZE) concentrations were determined by HPLC.