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为了解石家庄地区儿童病毒性脑炎病原学特点,同时研究病原学资料与临床资料之间的联系。本研究采用实验室全自动工作站,结合实时荧光定量PCR方法检测2015年10月~2016年9月河北省儿童医院神经内科收治的诊断为病毒性脑炎患儿的脑脊液样本,并结合临床资料进行分析。159例病毒性脑炎患儿中66例(41.5%)检出病毒阳性,肠道病毒58例,EB病毒3例,人疱疹病毒6型1例,4例为合并感染,分别为肠道病毒合并EB病毒3例,肠道病毒合并人疱疹病毒6型1例。肠道病毒是石家庄地区儿童病毒性脑炎最常见的病原。运用SPSS21.0统计分析软件对实验数据进行统计学分析。肠道病毒脑炎于炎热季节高发。不同病原病毒性脑炎患儿的年龄分布无显著差异。不同病原病毒性脑炎患儿的脑脊液样本采集时间分布无显著差异。不同病原病毒性脑炎患儿的临床症状和体征、MRI结果、EEG结果无显著差异。
To understand the etiological characteristics of children with viral encephalitis in Shijiazhuang, at the same time to study the relationship between etiological data and clinical data. In this study, CSF samples from children with viral encephalitis admitted to Department of Neurology, Children’s Hospital of Hebei Province from October 2015 to September 2016 were detected by real-time PCR with real-time fluorescence quantitative polymerase chain reaction (PCR) .Combined with clinical data analysis. Of the 159 cases of viral encephalitis, 66 cases (41.5%) were positive for the virus, 58 cases of enterovirus, 3 cases of Epstein-Barr virus and 1 case of human herpesvirus 6, and 4 cases were complicated with enterovirus 3 cases of combined EB virus, enterovirus combined human herpes virus type 6 in 1 case. Enterovirus is the most common cause of viral encephalitis in Shijiazhuang. Using SPSS21.0 statistical analysis software for statistical analysis of experimental data. Enterovirus encephalitis is high in the hot season. The age distribution of children with different pathogenic viral encephalitis had no significant difference. Cerebrospinal fluid samples collected from children with different pathogenic viral encephalitis showed no significant differences in time distribution. The clinical symptoms and signs of children with different pathogenic viral encephalitis, MRI results, EEG no significant difference.