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目的 探讨特异性神经元抗体 (SNA)对小细胞肺癌(SCLC)早期诊断的价值。方法 采用亲合免疫细胞组织化学ABC法对 90例高度怀疑为SCLC的患者血清进行检测 ,再用细胞学及病理学检查结果对上述病例进行分类 ,并分析二者间相互关系及其临床意义。结果 在 90例可疑患者中 ,34例患者血清与正常人大脑冰冻切片中所有神经元细胞核形成均匀染色 ,血清SNA阳性 ;5 6例患者血清与神经元细胞核无染色 ,血清SNA阴性。 72例患者为SCLC ,且全部为局限期 ,其中 31例 (43% )患者血清SNA阳性 ;18例患者为非SCLC ,其中 3例 (17% )患者血清SNA阳性 ;SCLC组SNA阳性率同非SCLC组阳性率差异有统计学意义 (χ2 =4 2 7,P <0 0 5 )。正常对照组血清无染色 ,全部为阴性。结论 SNA可以作为SCLC早期诊断的一项指标
Objective To investigate the value of specific neuronal antibody (SNA) in the early diagnosis of small cell lung cancer (SCLC). Methods Serum samples from 90 highly suspected patients with SCLC were assayed by affinity immunohistochemical ABC method. The cytological and pathological findings were used to classify the above cases. The relationship between them and their clinical significance were analyzed. Results In 90 suspicious patients, all the neuronal nuclei in frozen sections of 34 patients were homogenized and were positive for serum SNA. Serum and neuronal nuclei of 56 patients were non-stained and serum SNA was negative. Serum SNA was positive in 31 patients (43%), non-SCLC in 18 patients (SCLC), and SNA was positive in 3 patients (17%). The positive rate of SNA in SCLC was the same as that of non-SCLC The positive rate of SCLC group was significantly different (χ2 = 4 2 7, P <0 05). Normal control serum-free, all negative. Conclusion SNA can be used as an indicator of early diagnosis of SCLC