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目的 探讨DMBT1基因表达与胃癌的关系。方法 应用RT PCR方法检测胃癌及癌旁组织DMBT1基因的表达。结果 胃癌组织及癌旁组织DMBT1基因的表达率分别为 2 2 .9% (11/ 4 8)和 89.6 % (43/4 8) ;伴周围淋巴结转移的癌组织的DMBT1表达率 9.7% (3/ 31)均低于不伴周围淋巴结转移的癌组织的表达率76 .5 % (13/ 17) (P <0 .0 1) ,该基因的表达与肿瘤组织学分型、浸润方式及肿瘤大小等无关 (P均 >0 .0 5 )。结论 DMBT1基因表达率降低与胃癌转移有关 ,提示该基因在抑制肿瘤发生及肿瘤转移中起一定作用
Objective To investigate the relationship between DMBT1 gene expression and gastric cancer. Methods RT-PCR was used to detect the expression of DMBT1 gene in gastric cancer and its adjacent tissues. Results The expression rates of DMBT1 gene in gastric cancer tissue and paracancerous tissues were 22.9% (11/48) and 89.6% (43/48), respectively. The expression of DMBT1 in cancer tissues with peripheral lymph node metastasis was 9.7% (3) / 31) were lower than those in non-lymph node metastasis (76.5%, 13/17) (P <0.01) .The expression of this gene correlated with tumor histological type, infiltration type and tumor size (P> 0.05). Conclusion The decreased expression of DMBT1 gene is associated with gastric cancer metastasis, suggesting that this gene may play a role in tumorigenesis and tumor metastasis