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设计合成了10 个( E)3甲氧基4桂皮酰氧基苯乙烯侧链衍生物.其中9 个目标物未见文献报道.体内药理筛选结果表明,部分目标化合物具有不同程度的抗炎活性.并对侧链α碳取代的结构与活性间的关系进行了初步分析.
Design and synthesis of 10 (E) 3 methoxy 4 cinnamic acyloxy styrene side chain derivatives. Nine of them have not been reported in the literature. In vivo pharmacological screening results show that some of the target compounds have varying degrees of anti-inflammatory activity. The relationship between the structure and activity of side-chain α-carbon substitution was also analyzed.