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目的 观察小容量高渗氯化钠 醋酸钠溶液 (HSA)对失血性休克大鼠的治疗作用。方法 Wistar大鼠随机分成 0 .9%NaCl(NS)、7.5 %NaCl(HS)、5 .0 %NaCl 3.5 %NaAc(HSA) 3组。放血于 10min内使平均动脉压降至 5 .3kPa( 1kPa =7.5mmHg) ,维持 90min。随后分别按 4ml/kg体重静脉注入NS、HS、HSA ,5min内输完。测定休克前、后及给液后心肌收缩性能、动脉血气 ,并观察存活率。结果 与NS组比较 ,HSA和HS均能显著升高平均动脉压 [90min时 ,平均动脉压NS( 3.2 0± 2 .93)kPa ,HSA ( 7.2 0± 3.99)kPa(P <0 .0 5 ) ,HS( 7.69± 3.42 )kPa(P <0 .0 1) ] ,改善心肌收缩性能 [90min时 ,LVSPNS( 5 .33± 4.78)kPa ,HSA( 10 .99± 6.65 )kPa(P <0 .0 5 ) ,HS( 11.5 8± 6.18)kPa(P <0 .0 5 ) ]。与NS组比较 ,HSA显著减轻代谢性酸中毒 [90min时 ,pH值NS 7.2 96± 0 .0 48,HSA 7.15 9± 0 .15 3(P <0 .0 5 ) ] ,提高 2 4h存活率 (NS 18.2 % ,HAS75 .0 % ,P <0 .0 5 ) ,主要指标优于HS组。结论 HSA是一种较HS治疗失血性休克更为有效的复苏溶液。
Objective To observe the therapeutic effect of small volume hypertonic sodium chloride sodium acetate solution (HSA) on hemorrhagic shock rats. Methods Wistar rats were randomly divided into 3 groups: 0.9% NaCl (NS), 7.5% NaCl (HS) and 5.0% NaCl 3.5% NaAc (HSA). Bleeding in the average arterial pressure within 10min to 5. 3kPa (1kPa = 7.5mmHg), maintained 90min. Followed by 4ml / kg body weight intravenous injection of NS, HS, HSA, 5min lost. Before and after shock and myocardial systolic performance, arterial blood gas, and observe the survival rate. Results Compared with NS group, both HSA and HS significantly increased mean arterial pressure (mean arterial pressure NS (3.2 ± 2.93) kPa and HSA (7.2 ± 3.99) kPa (P <0. 05 ) And HS (7.69 ± 3.42) kPa (P <0.01), respectively. The myocardial systolic function was improved by LVSPNS (5.33 ± 4.78) kPa and HSA (10.99 ± 6.65) kPa .0 5), HS (11.5 8 ± 6.18) kPa (P <0.05)]. Compared with the NS group, HSA significantly reduced metabolic acidosis (pH 7.2 ± 0.48 48 and HSA 7.15 9 ± 0.15 3 (P <0.05) at 90 min, and increased the survival rate at 24 h (NS 18.2%, HAS75.0%, P <0.05), the main indexes were better than HS group. Conclusion HSA is a more effective resuscitation solution than HS for hemorrhagic shock.