给兔icv毛果芸香碱,出现抽搐、流涎、咀嚼,脑电呈低幅快波,呼吸兴奋,icv槟榔碱,兔轻度抽搐、流涎,脑电呈双相反应,呼吸兴奋作用短暂;icv氨甲酰甲胆碱,兔亦出现抽搐、流涎、咀嚼及脑电低幅快波反应,但呼吸变化不一,或为加快,或为减慢。提示三种拟胆碱药中枢作用不完全相同,其原因可能与选择性激动中枢不同亚型M受体有关。上述三药均引起心率减慢。 Icv carboxamide, rabbits mild convulsions, salivation, electroencephalogram showed biphasic response, short-term respiratory excitement; icv carbamoyl, convulsions, salivation, chewing, electroencephalogram was slow wave fast, Choline, rabbit also appear convulsions, salivation, chewing and electroencephalogram fast response wave, but the breathing varies, or to speed up, or to slow down. Suggesting that the three kinds of cholinergic center role is not exactly the same, the reason may be selective activation center of different subtype M receptor. The three drugs are caused by slow heart rate.