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近有报道,再生障碍性贫血(再障)患者的淋巴细胞可抑制 HLA 不同的无亲缘关系的健康人体外造血集落的生长,提示某些再障的病例有一个免疫病因学。但随后的研究又表示由于经过输血而致敏的患者其淋巴细胞在体外可以抑制 HLA 不相同的粒系细胞集落(CFU-C)的生长。而再障病例又常经过反复的输血。因此作者进行了下列研究来进行区分。作者对42例再障,研究是否由于输血所诱导的致敏使患者的淋巴细胞在体外能抑制 HLA 相同的红细胞爆增生长单位(BFU-E)。研究结果经输血的34例有12例的淋巴细胞抑制正常的造血细胞集落生长。相反,未经输血的8例都未出现这种抑制。这些资料意味着曾输血的患者其细胞共同培养技术对确定免疫
It has recently been reported that lymphocytes from patients with aplastic anemia (aplastic anemia) can inhibit the growth of hematopoietic colonies in healthy unrelated HLA-related individuals in vitro, suggesting that there is an immunogenic etiology in some cases of aplastic anemia. However, subsequent studies show that lymphocytes in vitro can inhibit the growth of non-HLA-identical granulocyte colony (CFU-C) in patients sensitized by transfusion. Patients with aplastic anemia often undergo repeated blood transfusions. Therefore, the authors conducted the following research to make a distinction. The authors of 42 patients with aplastic anemia, to study whether due to sensitization caused by blood transfusion in patients with lymphocytes can inhibit HLA identical erythrocyte burst growth units (BFU-E) in vitro. Results Of the 34 transfusions, 12 of 12 lymphocytes inhibited normal hematopoietic colony growth. In contrast, none of the eight transfused patients did not show this inhibition. These data mean that patients who have previously transfused their cells co-culture techniques to determine immunity