刺激性物质作用机体后会引起机体发生一系列的生理、生化改变,其中最主要的是产生刺激反应。刺激反应可导致水肿、红斑等客观表现和瘙痒、疼痛等主观感觉[1]。如果机体受到刺激物单次、重复或持续作用则会导致刺激性接触性皮炎,刺激性接触性皮炎是皮肤对直接损伤产生炎症反应的结果。引起刺激性反应的物质大多数为化学物质,而化妆品是日常生活中接 Irritant substances in the body will cause the body to a series of physiological and biochemical changes, the most important of which is to stimulate the reaction. Stimulus response can lead to subjective perception of edema, erythema and other objective manifestations and itching, pain and other [1]. If the body is stimulated by a single, repeated or sustained action can lead to irritant contact dermatitis, irritant contact dermatitis is the result of direct skin inflammation and inflammation. Most of the substances that cause irritation are chemical substances, while cosmetics are used in daily life