迄今已有不少观察,证明化学致癌物可诱导皮肤黑色素母细胞(melanoblasts)的黑色素形成(melanogenesis)。因此,提出黑色素细胞激活作用(melanocyte activation)可用作为检测化学致癌物的方法之一。为进一步对这种测试系统作出评价,本研究应用多种强致癌物,弱致癌物,肿瘤促进剂,以及非致癌物质对有色素成年小鼠内毛囊表皮(interfollicular epidermis)黑色素细胞的作用。 There have been many observations to date that chemical carcinogens can induce melanogenesis in melanoblasts of the skin. Therefore, melanocyte activation has been proposed as one of the methods for detecting chemical carcinogens. To further evaluate this type of test system, this study used a variety of strong carcinogens, weak carcinogens, tumor promoters, and non-carcinogenic substances to act on pigmented adult hair follicle epidermis melanocytes.