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目的:探讨早期生大黄治疗后重度颅脑损伤患者外周血TNF-α,IL-6含量的变化及临床意义。方法:将52例重型颅脑损伤患者随机分为生大黄组27例,对照组25例;两组基础治疗相同,生大黄组伤后24h给予生大黄粉经鼻胃管鼻饲,每次0.1g/kg,监测两组患者伤后24h、第3天、第14天的外周血TNF-α、IL-6含量、治疗间期的GCS变化。结果:生大黄组的TNF-α、IL-6含量低,且下降明显,与对照组相比有显著差异性(P<0.05),GCS相比有显著差异性(P<0.05)。结论:在重度颅脑损伤早期生大黄治疗可以抑制炎症介质的释放,防止肠道细菌移位及调节免疫抑制,防止继发性脑损害,在重型颅脑损伤的治疗中有着重要意义。
Objective: To investigate the changes and clinical significance of TNF-α and IL-6 in the peripheral blood of patients with severe craniocerebral injury after treatment with rhubarb. Methods: 52 cases of severe craniocerebral injury were randomly divided into rhubarb group of 27 cases, control group of 25 cases; two groups of the same basic treatment, rhubarb rhubarb powder after injury to nasal feeding rhubarb nasal feeding, each 0.1g / kg. The levels of TNF-α and IL-6 in the peripheral blood and GCS in the treatment group were monitored at 24h, 3d and fourteenth after injury. Results: The content of TNF-α and IL-6 in raw rhubarb group was lower than that in control group (P <0.05), and the difference was significant (P <0.05). Conclusion: Rhubarb treatment can inhibit the release of inflammatory mediators, prevent intestinal bacterial translocation and regulate immunosuppression in the early stage of severe craniocerebral injury and prevent secondary brain damage. It is of great significance in the treatment of severe craniocerebral injury.