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目的:观察中西医结合治疗重症胰腺炎的疗效。方法:将82例重症胰腺炎患者随机分为A、B、C组,3组均给予常规治疗,B组加用注射用乌司他丁静脉滴注,C组加用注射用乌司他丁静脉滴注联合生大黄煎液灌肠治疗。观察3组患者的临床疗效、腹痛缓解时间、肠功能恢复时间、肛门排气时间、排便恢复时间。并随时监测患者的血淀粉酶、尿淀粉酶、白细胞计数、肌酐、谷丙转氨酶水平,治疗前后测定肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)的水平。结果:C组腹痛缓解时间、肠功能恢复时间、肛门排气时间、排便恢复时间均短于A、B组,差异均有统计学意义(P<0.05,P<0.01)。C组血淀粉酶、尿淀粉酶、白细胞计数、肌酐、谷丙转氨酶改善情况均优于A、B组,差异均有统计学意义(P<0.05,P<0.01)。C组TNF-α、IL-6、IL-8改善情况均优于A、B组,差异均有统计学意义(P<0.05)。结论:采用中西医结合治疗重症胰腺炎,能明显提高疗效,缩短症状缓解时间,促进实验室指标恢复到正常水平。
Objective: To observe the curative effect of integrated traditional Chinese and western medicine on severe pancreatitis. Methods: Eighty-two patients with severe acute pancreatitis were randomly divided into A, B and C groups. All the three groups were given routine treatment. In group B, intravenous injection of ulinastatin was used, in group C, ulinastatin Intravenous drip combined rhubarb decoction enema treatment. The clinical efficacy, abdominal pain relief time, intestinal function recovery time, anal exhaust time and defecation recovery time were observed in 3 groups of patients. The serum amylase, urinary amylase, white blood cell count, creatinine and alanine aminotransferase levels were monitored at any time. The levels of TNF-α, IL-6 and leukocyte Su-8 (IL-8) levels. Results: The pain relief time, intestinal function recovery time, anal exhaust time and defecation recovery time in group C were shorter than those in groups A and B (P <0.05, P <0.01). The improvement of serum amylase, urinary amylase, white blood cell count, creatinine, and alanine aminotransferase in group C were better than those in group A and group B, the difference was statistically significant (P <0.05, P <0.01). The improvement of TNF-α, IL-6 and IL-8 in group C were better than those in group A and B (P <0.05). Conclusion: The treatment of severe acute pancreatitis by integrated traditional Chinese and western medicine can significantly improve the curative effect, shorten the time of symptom relief and promote the recovery of laboratory indexes to normal levels.