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目的：观察荷瘤小鼠体内各器官组织铜锌的变化及口服醋酸铜（１５０ｍｇ／ｋｇ）后铜、锌在体内的动态分布过程。方法：用Ｂａｌｂ／Ｃ小鼠造成实体瘤模型，用原子吸收方法测定组织中的铜锌含量。结果：荷瘤小鼠肝脏及胃肠组织的铜水平明显低于正常对照组（均Ｐ＜００１），血清及脾脏组织高于对照组（均Ｐ＜００１）。与此同时心脏组织及血清的锌含量较正常对照组出现有意义的下降（均Ｐ＜００５），而肝脏、脾脏则出现有意义的升高（Ｐ＜００５，Ｐ＜００１）。荷瘤小鼠口服铜盐后，所观察的组织中先后出现不同程度的升高。铜高值出现在０５ｈ的是血清；到２ｈ的有心脏、脾脏、肺脏、肾脏、胃肠，而５ｈ时血细胞、肿瘤组织出现最高值；肝脏组织的铜在１２ｈ时仍在上升；锌随着铜的变化而变化，锌高值出现的时间一般与铜出现高值的时间同步或后移（除肝脏）。结论：荷瘤使机体内铜锌分布发生变化，血清铜升高、肝脏及胃肠等重要组织中的铜降低。给铜后，荷瘤小鼠体内铜、锌的动态变化因组织不同而异，肝脏是铜聚集的主要器官
Objective: To observe the changes of copper and zinc in organs of tumor-bearing mice and the dynamic distribution of copper and zinc in vivo after oral administration of copper acetate (150 mg/kg). METHODS: A solid tumor model was established in Balb/C mice and the copper and zinc contents in tissues were determined by atomic absorption spectroscopy. Results: The levels of copper in the liver and gastrointestinal tissues of tumor-bearing mice were significantly lower than those in the normal control group (all P<001), and the serum and spleen tissues were higher than those in the control group (all P<001). At the same time, the content of zinc in heart tissue and serum had a significant decrease compared with the normal control group (all P<005), but there was a significant increase in liver and spleen (P<005, P<0). 01). After oral administration of copper salts in tumor-bearing mice, different degrees of elevation were observed in the observed tissues. The high copper value appeared at 05h with serum; at 2h, there was heart, spleen, lung, kidney, and gastrointestinal tract, and blood cells and tumor tissues appeared at the highest value at 5h; copper in liver tissue increased at 12h; zinc As the copper changes, the time at which the high value of zinc occurs is usually synchronized or shifted backward (except for the liver). Conclusion: The tumor-bearing tumor changes the distribution of copper and zinc in the body, the serum copper is elevated, and the copper in the liver and gastrointestinal tissues is reduced. After copper was administered, the dynamic changes of copper and zinc in tumor-bearing mice varied with different tissues. The liver was the main organ for copper accumulation.