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目的 寻找揭示帕金森病患者轻度认知损害的敏感指标。方法 30例非痴呆帕金森病患者和 34名年龄匹配的正常对照参与本研究。成对的刺激 (S1和S2 )依次呈现 ,共有两种类型 :(1)S1和S2颜色匹配 ;(2 )S1和S2颜色冲突。受试者比较S1和S2颜色是否相同 ,同时在头皮记录事件相关电位。结果 无论患者组还是对照组 :颜色匹配时 ,S2诱发出P10 0、N15 0、P180、N2 0 0和P30 0 ;冲突时 ,在N2 0 0后P30 0前又出现了另一个负波———N2 70。两组间N15 0的潜伏期以及振幅均无显著性差异。患者组N2 70的峰潜伏期长于对照组 [P3,患者组 (317± 37)ms,对照组 (2 98± 31)ms];振幅低于对照组 [P3,患者组 (- 3 1± 2 5 ) μV ,对照组 (- 4 6± 2 9) μV]。患者组P30 0的峰潜伏期与对照组无显著性差异 ,仅峰振幅低于对照组。结论 非痴呆帕金森病患者存在认知功能损害 ,N2 70在检测这一认知损害时比P30 0更敏感。
Objective To find out the sensitive indicators to reveal mild cognitive impairment in patients with Parkinson’s disease. Methods Thirty non-demented Parkinson’s disease patients and 34 age-matched normal controls were enrolled in this study. Pairs of stimuli (S1 and S2) are presented in turn, with two types: (1) S1 and S2 color matching; and (2) S1 and S2 color conflicts. Subjects compared S1 and S2 color is the same, while recording the event-related potential in the scalp. Results In the case of color matching, S2 induced P10 0, N15 0, P180, N2 0 0 and P30 0 in the case of color matching. In the case of conflict, another negative wave appeared before P30 0 after N2 0 0, -N2 70. There was no significant difference in latency and amplitude of N15 0 between the two groups. The peak latency of N270 in patient group was longer than that in control group [P3 (317 ± 37) ms, control group (988 ± 31) ms]; the amplitude was lower than that in control group [P3, ) μV, control group (- 46 ± 2 9) μV]. The peak latency of P30 0 in patients group was not significantly different from that in control group, and only the peak amplitude was lower than that in control group. Conclusion There is cognitive impairment in patients with dementia without Parkinson’s disease, and N2 70 is more sensitive than P30 in detecting this cognitive impairment.