论文部分内容阅读
目的探讨血清DNA酶Ⅰ(DNaseⅠ)、超敏C反应蛋白(hs-CRP)质量浓度与冠状动脉病变范围、病变程度和临床风险的关系。方法选取2006年7月至12月华中科技大学同济医学院附属协和医院心内科住院患者,根据冠状动脉造影和临床表现,对112例冠心病(CHD)患者和57名正常人的血清DNaseⅠ与hs-CRP质量浓度进行比较。结果DNaseⅠ在稳定型心绞痛组[(152.63±24.16)μg/L]与对照组[(159.62±20.51)μg/L]差异无显著性意义(P>0.05),在不同冠状动脉病变范围组间、不同冠状动脉病变程度组间、急性冠脉综合征(ACS)与稳定型心绞痛组间的DNaseⅠ差异均有显著性意义(P<0.05);hs-CRP在单支病变组[(5.81±3.59)mg/L]和多支病变组[(6.62±5.18)mg/L]差异无显著性意义(P>0.05),在不同冠状动脉病变程度组间、不同临床分组间hs-CRP差异均有显著性意义(P<0.01)。冠心病患者血清DNaseⅠ和hs-CRP呈显著正相关(r=0.295,P<0.01)。结论联合检测DNaseⅠ与hs-CRP质量浓度有助于判断冠状动脉病变范围、病变程度和临床风险。
Objective To investigate the relationship between the serum DNase Ⅰ, hs-CRP concentration and the extent of coronary lesion, the degree of lesion and clinical risk. Methods From July 2006 to December 2006, Huazhong University of Science and Technology Tongji Medical College Affiliated Union Hospital, Department of Cardiology inpatients, according to coronary angiography and clinical manifestations of 112 patients with coronary heart disease (CHD) and 57 normal subjects serum DNase Ⅰ and hs -CRP mass concentration for comparison. Results There was no significant difference in the DNase Ⅰ level between the patients with stable angina (152.63 ± 24.16 μg / L) and the control group (159.62 ± 20.51 μg / L) (P> 0.05) There were significant differences in DNaseⅠbetween acute coronary syndrome (ACS) and stable angina pectoris group (P <0.05), while in the single coronary artery disease group (5.81 ± 3.59) (P <0.05). There were significant differences in hs-CRP between different clinical groups in different degree of coronary artery disease Sexual significance (P <0.01). Serum DNase I and hs-CRP were positively correlated with coronary heart disease (r = 0.295, P <0.01). Conclusion The combined detection of DNase Ⅰ and hs-CRP mass concentration is helpful to determine the extent of coronary artery lesions, the degree of lesion and clinical risk.