【摘 要】
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Objective:The present study investigates the effects of co-exposure to lead and cadmium on mice testis using histomorphological approach.Methods:Male mice were
【机 构】
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Department of Biology, Research Centre on Ceramic and Composite Materials, University of Aveiro, 381
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Objective:The present study investigates the effects of co-exposure to lead and cadmium on mice testis using histomorphological approach.Methods:Male mice were subcutaneously injected with lead chloride on day1 and cadmium chloride on day2(74 and1 mg/kg body weight, respectively), and kept for24 h.Vehicle control group was also considered.Mice were then sacrificed and testis were collected and weighed.Samples were fixed onBouin′s solution and processed for histology.The diameter of seminiferous tubules in both groups was calculated using software based on deformable models(SNAKE).Results:The combined exposure of lead and cadmium induced degenerative changes in testis, namely, wavy contour of seminiferous tulules, germ cell loss, and release of immature cells into the lumen.Atrophy of seminiferous tubules was seen in this group, confirmed by a significant(P<0.001) decrease in the diameter.Conclusions:Cumulative effects of lead and cadmium may have disrupted the blood-testis barrier, then causing the histopathological lesions within testis.
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