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白介素３（ＩＬ－３）具有刺激多能造血干细胞、髓样、红样、单核、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞及肥大细胞增殖与分化的功能，又称为多重集落刺激因子。ＩＬ－３的水平异常与许多疾病的发生与发展有密切的关系。机体在正常的情况下ＩＬ－３的表达受到严格的负反馈调控，但是当病毒感染、染色体异位等原因激活了ＩＬ－３基因，致使ＩＬ－３过量表达，可引起某些类型的白血病的发生。此外，ＩＬ－３还能促进嗜酸性粒细胞和嗜碱性粒细胞的生长、分化和效应功能的发挥，从而在哮喘等过敏性疾病中充当了重要的角色。因此，拮抗ＩＬ－３的一些措施可能在白血病、过敏性疾病中有潜在的治疗价值。
Interleukin 3 (IL-3) has the function of stimulating the proliferation and differentiation of pluripotent hematopoietic stem cells, medullary, reddish, mononuclear, neutrophils, eosinophils, basophils, and mast cells. Multiple colony stimuli. Abnormal levels of IL-3 are closely related to the occurrence and development of many diseases. Under normal conditions, the body’s expression of IL-3 is strictly controlled by negative feedback, but IL-3 gene is activated when viral infections, ectopic chromosomes, etc. cause overexpression of IL-3, which can cause certain types of leukemia. occur. In addition, IL-3 can also promote the growth, differentiation and effector functions of eosinophils and basophils, and thus play an important role in allergic diseases such as asthma. Therefore, some measures to antagonize IL-3 may have potential therapeutic value in leukemia and allergic diseases.