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目的:研究小陷胸汤加味方对心肌缺血再灌注心肌的作用。方法:将32只健康家兔随机分为4组,假手术组(C组),小陷胸汤加味方高剂量组(D组),每组8只。A组不予缺血再灌注处理,C、D两组提前5天连续灌胃中药,A、B组各灌以等量0.9%NaCl溶液。B、C、D三组建立心肌缺血再灌注模型。各组分别于再灌注120min检测血清磷酸肌酸激酶(CK),肿瘤坏死因子-α(T.F-α)的含量。结果:C、D两组CK、T.F-α均低于B组(P<0.05),C、D两组间CK、T.F-α无差异(P>0.05)。结论:小陷胸汤加味方可降低兔心肌缺血再灌注CK、T.F-α含量,对心肌缺血再灌注损伤具有保护作用。
Objective: To study the effect of Xiaoxianxiong Tang Jiawei recipe on myocardium ischemia-reperfusion myocardium. METHODS: Thirty-two healthy rabbits were randomly divided into 4 groups: sham operation group (C group), Xiaoxianxiong Tang Jiaweifang high dose group (D group), 8 rats in each group. In group A, no ischemia-reperfusion treatment was performed. In groups C and D, Chinese herbs were continuously administered for 5 days in advance, and groups A and B were each given equal amount of 0.9% NaCl solution. B, C, D three groups to establish myocardial ischemia reperfusion model. Serum phosphocreatine kinase (CK) and tumor necrosis factor-α (T.F-α) levels were measured in each group 120 min after reperfusion. Results: The levels of CK and T.F-α in group C and D were lower than those in group B (P<0.05). There was no difference in CK and T.F-α between groups C and D (P>0.05). Conclusion: Xiaoxianxiong Tang Jiawei can reduce myocardial ischemia and reperfusion in rabbits CK, T.F-α content, has a protective effect on myocardial ischemia and reperfusion injury.